Human Medicine:

FIT testing: a vital tool in the diagnosis of bowel cancer

Published: 16th April 2025 - All information correct at time of publication.

Taking the awkwardness out of bowel cancer

Almost 44,000 people in the UK are diagnosed with bowel cancer every year, making it the fourth most common cancer. However, according to Bupa, discussions and awareness around bowel cancer are seen as taboo and rarely talked about. Not only can this lead to misinformation but, crucially, may prevent someone seeking help when they need it.

Being aware of the symptoms of bowel cancer is the first step in ensuring more people know when something isn’t right with their body and require investigative tests.

Main symptoms include:

Who has an increased risk of developing bowel cancer?

Researchers don’t know what causes bowel cancer and while anyone can develop the disease, there are certain groups who have an increases risk factor.

Bowel Cancer UK identify the at risk groups as:

How a FIT test can help

A Faecal Immunochemical Test (FIT) analyses a stool specimen for blood and while it isn’t a diagnostic test, if blood is found in the stool, this is classed as a positive FIT test and further tests can be conducted.

In England, Scotland and Wales, everyone aged 50 to 74 will be invited to undertake an NHS FIT test every two years as part of a bowel screening programme.

The FIT test uses specific antibodies to detect blood in stool which is not visible to the naked eye.  The specimen is collected in the privacy of the individual’s own home by simply inserting a small ‘stool picker’ (looking a little like a grooved cocktail stick) into a stool sample.  The sample is placed in a container with a buffer, sealed and posted to the laboratory for analysis.  The technology associated with the ‘stool picker’ means a set amount of stool is sampled and analysed.

Understanding the results of a FIT test

In the laboratory, the container is placed on an automated analyser, which uses Integrated Sphere Latex Turbidimetry to determine the amount of blood per gram of stool present in the sample.  This means the analyser assesses the degree of cloudiness in the sample by measuring the loss of intensity of a light beam passed through it; this is directly proportional to the amount of blood present.

Results are expressed as amount of blood per gram of stool. Results of at least 10 ug blood per gram of stool suggest urgent referral for further testing should occur.  Results below 10 ug effectively rule out bowel cancer unless there is a strong clinical suspicion of the disease.

How SYNLAB can support your people

Whether you’re looking to implement a wellbeing testing programme for your employees, or an insurance company needing to offer tests to clients, our UK pathology laboratory can support. We carry out thousands of FIT tests every year to help people get a better understanding of their health.

For more information, get in touch with us at https://synlab.co.uk/synlab-laboratory-services/


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